@font-face{font-family:Inter Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/inter-cyrillic-ext-wght-normal.BOeWTOD4.woff2)format("woff2-variations");unicode-range:U+460-52F,U+1C80-1C8A,U+20B4,U+2DE0-2DFF,U+A640-A69F,U+FE2E-FE2F}@font-face{font-family:Inter Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/inter-cyrillic-wght-normal.DqGufNeO.woff2)format("woff2-variations");unicode-range:U+301,U+400-45F,U+490-491,U+4B0-4B1,U+2116}@font-face{font-family:Inter Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/inter-greek-ext-wght-normal.DlzME5K_.woff2)format("woff2-variations");unicode-range:U+1F??}@font-face{font-family:Inter Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/inter-greek-wght-normal.CkhJZR-_.woff2)format("woff2-variations");unicode-range:U+370-377,U+37A-37F,U+384-38A,U+38C,U+38E-3A1,U+3A3-3FF}@font-face{font-family:Inter Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/inter-vietnamese-wght-normal.CBcvBZtf.woff2)format("woff2-variations");unicode-range:U+102-103,U+110-111,U+128-129,U+168-169,U+1A0-1A1,U+1AF-1B0,U+300-301,U+303-304,U+308-309,U+323,U+329,U+1EA0-1EF9,U+20AB}@font-face{font-family:Inter Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/inter-latin-ext-wght-normal.DO1Apj_S.woff2)format("woff2-variations");unicode-range:U+100-2BA,U+2BD-2C5,U+2C7-2CC,U+2CE-2D7,U+2DD-2FF,U+304,U+308,U+329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF}@font-face{font-family:Inter Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/inter-latin-wght-normal.Dx4kXJAl.woff2)format("woff2-variations");unicode-range:U+??,U+131,U+152-153,U+2BB-2BC,U+2C6,U+2DA,U+2DC,U+304,U+308,U+329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD}@font-face{font-family:Fraunces Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/fraunces-vietnamese-wght-normal.CnvboYUG.woff2)format("woff2-variations");unicode-range:U+102-103,U+110-111,U+128-129,U+168-169,U+1A0-1A1,U+1AF-1B0,U+300-301,U+303-304,U+308-309,U+323,U+329,U+1EA0-1EF9,U+20AB}@font-face{font-family:Fraunces Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/fraunces-latin-ext-wght-normal.Ca2vKHc0.woff2)format("woff2-variations");unicode-range:U+100-2BA,U+2BD-2C5,U+2C7-2CC,U+2CE-2D7,U+2DD-2FF,U+304,U+308,U+329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF}@font-face{font-family:Fraunces Variable;font-style:normal;font-display:swap;font-weight:100 900;src:url(/_astro/fraunces-latin-wght-normal.ukD16Tqj.woff2)format("woff2-variations");unicode-range:U+??,U+131,U+152-153,U+2BB-2BC,U+2C6,U+2DA,U+2DC,U+304,U+308,U+329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD}:root{--font-sans:"Inter Variable", system-ui, -apple-system, "Segoe UI", Roboto, sans-serif;--font-display:"Fraunces Variable", Georgia, "Times New Roman", serif;--bg:#f6f4ef;--bg-tint:#efece4;--surface:#fff;--surface-2:#faf9f6;--surface-3:#f2f0ea;--text:#17191e;--text-2:#3d414a;--muted:#6b6f78;--border:#e6e2d8;--border-strong:#d6d1c4;--accent:#2d4fd6;--accent-ink:#1d3aa8;--accent-soft:#edf0fd;--accent-ring:#2d4fd62e;--good:#17733f;--good-bg:#e6f4ea;--caution:#94580a;--caution-bg:#fcf1dc;--bad:#b02a2a;--bad-bg:#fbe8e6;--neutral:#4b505a;--neutral-bg:#eeede8;--focus:#2d4fd6;--radius-sm:8px;--radius:14px;--radius-lg:20px;--shadow-sm:0 1px 2px #17191e0d;--shadow:0 1px 2px #17191e0a, 0 8px 24px -8px #17191e14;--shadow-lg:0 24px 64px -16px #17191e47, 0 2px 6px #17191e0f;color-scheme:light}[data-theme=dark]{--bg:#111215;--bg-tint:#16181c;--surface:#191b20;--surface-2:#1d1f25;--surface-3:#24272e;--text:#edebe6;--text-2:#c9c7c1;--muted:#9a9ca4;--border:#2b2e35;--border-strong:#3a3e47;--accent:#93abff;--accent-ink:#b5c5ff;--accent-soft:#1e2540;--accent-ring:#93abff40;--good:#7fd8a0;--good-bg:#15291d;--caution:#f2c46b;--caution-bg:#32270f;--bad:#f4a19a;--bad-bg:#351816;--neutral:#c9cbd2;--neutral-bg:#262930;--focus:#93abff;--shadow-sm:0 1px 2px #0000004d;--shadow:0 1px 2px #0000004d, 0 8px 24px -8px #0006;--shadow-lg:0 24px 64px -16px #000000b3;color-scheme:dark}*,:before,:after{box-sizing:border-box}html{-webkit-text-size-adjust:100%;scroll-padding-top:5rem}@media (prefers-reduced-motion:no-preference){html{scroll-behavior:smooth}}body{background:var(--bg);color:var(--text);font-family:var(--font-sans);font-feature-settings:"cv11", "ss01";-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale;margin:0;font-size:1.0625rem;line-height:1.6}a{color:var(--accent);text-underline-offset:.18em;text-decoration-thickness:1px}a:hover{color:var(--accent-ink);text-decoration-thickness:2px}:focus-visible{outline:3px solid var(--focus);outline-offset:2px;border-radius:4px}::selection{background:var(--accent-soft)}h1,h2,h3,h4{letter-spacing:-.01em;margin:1.6em 0 .5em;font-weight:650;line-height:1.2}h1,h2{font-family:var(--font-display);font-variation-settings:"opsz" 96, "SOFT" 30;letter-spacing:-.02em;font-weight:560}h1{margin-top:.3em;font-size:clamp(2.2rem,4.6vw,3.6rem);line-height:1.06}h1 em{color:var(--accent);font-style:italic;font-weight:480}h2{font-size:clamp(1.5rem,2.4vw,1.9rem)}h3{font-size:1rem}.wrap{max-width:1560px;margin:0 auto;padding:0 clamp(1rem,3vw,2.5rem)}.muted{color:var(--muted)}.small{font-size:.875rem}.lede{color:var(--text-2);max-width:40rem;font-size:1.2rem;line-height:1.55}.eyebrow{text-transform:uppercase;letter-spacing:.08em;color:var(--muted);margin:0;font-size:.75rem;font-weight:650}.visually-hidden{clip:rect(0 0 0 0);white-space:nowrap;width:1px;height:1px;overflow:hidden;position:absolute!important}.skip{background:var(--surface);border-radius:var(--radius-sm);z-index:50;padding:.6rem 1rem;position:absolute;top:.5rem;left:-999px}.skip:focus{left:.5rem}.site-header{z-index:20;background:color-mix(in srgb, var(--bg) 82%, transparent);-webkit-backdrop-filter:saturate(1.4)blur(14px);border-bottom:1px solid color-mix(in srgb, var(--border) 70%, transparent);position:sticky;top:0}.header-inner{flex-wrap:wrap;align-items:center;gap:1rem;min-height:4.25rem;padding-top:.5rem;padding-bottom:.5rem;display:flex}.brand{letter-spacing:-.01em;color:var(--text);align-items:center;gap:.6rem;margin-right:auto;font-size:1.1rem;font-weight:700;text-decoration:none;display:inline-flex}.brand:hover{color:var(--text)}.brand-mark{width:2rem;height:2rem}.brand-mark rect{fill:var(--accent)}.brand-mark path{fill:none;stroke:var(--surface);stroke-width:2.6px;stroke-linecap:round;stroke-linejoin:round}.site-header nav ul{flex-wrap:wrap;gap:.15rem;margin:0;padding:0;list-style:none;display:flex}.site-header nav a{color:var(--text-2);border-radius:999px;padding:.55rem .85rem;font-size:.95rem;font-weight:500;text-decoration:none;display:block}.site-header nav a:hover{background:var(--surface-3);color:var(--text)}.site-header nav a[aria-current=page]{background:var(--text);color:var(--bg)}.theme-toggle{border:1px solid var(--border);background:var(--surface);width:2.75rem;height:2.75rem;color:var(--text);cursor:pointer;border-radius:50%;place-items:center;display:grid}.theme-toggle:hover{border-color:var(--border-strong)}.theme-toggle svg{fill:none;stroke:currentColor;stroke-width:2px;stroke-linecap:round;stroke-linejoin:round;width:1.15rem;height:1.15rem}.icon-sun,[data-theme=dark] .icon-moon{display:none}[data-theme=dark] .icon-sun{display:block}main.wrap{padding-bottom:clamp(3rem,6vw,5rem)}.site-footer{border-top:1px solid var(--border);background:var(--bg-tint);padding:2.5rem 0;font-size:.925rem}.footer-inner{flex-wrap:wrap;justify-content:space-between;gap:1.5rem 3rem;display:flex}.footer-inner>div{max-width:36rem}.footer-inner p{margin:0 0 .35rem}.footer-brand{font-weight:700}.footer-links{gap:.35rem;margin:0;padding:0;list-style:none;display:grid}.button{font:inherit;background:var(--text);min-height:2.75rem;color:var(--bg);cursor:pointer;border:1px solid #0000;border-radius:999px;align-items:center;gap:.4rem;padding:.6rem 1.2rem;font-size:.95rem;font-weight:600;text-decoration:none;display:inline-flex}.button:hover{color:var(--bg);background:color-mix(in srgb, var(--text) 85%, var(--accent));text-decoration:none}.button-ghost{color:var(--text);border-color:var(--border-strong);background:0 0}.button-ghost:hover{background:var(--surface);color:var(--text)}.link-button{font:inherit;color:var(--text-2);cursor:pointer;background:0 0;border:0;align-items:center;gap:.4rem;min-height:2.75rem;padding:0 .25rem;font-size:.9rem;font-weight:500;display:inline-flex}a.link-button{text-decoration:none}.link-button:hover{color:var(--accent)}.popup-tools{flex-wrap:wrap;gap:0 1rem;display:flex}.hero{grid-template-columns:minmax(0,1.5fr) minmax(0,1fr);align-items:end;gap:2rem 4rem;padding:clamp(2rem,6vw,4.5rem) 0 clamp(2rem,4vw,3rem);display:grid}.hero-links{flex-wrap:wrap;gap:.6rem;margin:1.75rem 0 0;display:flex}.stats{grid-template-columns:repeat(2,1fr);gap:.75rem;margin:0;display:grid}.stats>div{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius);box-shadow:var(--shadow-sm);padding:1.1rem 1.25rem}.stats dt{color:var(--muted);font-size:.85rem;font-weight:500}.stats dd{font-family:var(--font-display);letter-spacing:-.02em;margin:.15rem 0 0;font-size:2.4rem;font-weight:500;line-height:1.1}.stats dd.stat-note{font-family:var(--font-sans);letter-spacing:0;color:var(--muted);margin:.2rem 0 0;font-size:.8rem;font-weight:400;line-height:1.4}.early-note{max-width:72ch;margin-bottom:1rem}.intro{padding:clamp(1.5rem,4vw,3rem) 0 .5rem}.block{margin-top:2.5rem}.section-head{flex-wrap:wrap;justify-content:space-between;align-items:baseline;gap:.25rem 2rem;margin-bottom:1rem;display:flex}.section-head h2{margin:0}.section-head p{max-width:40rem;margin:0}.filters{flex-wrap:wrap;align-items:flex-end;gap:.75rem;margin:0 0 1rem;display:flex}.filters label{color:var(--muted);flex-direction:column;gap:.3rem;font-size:.8rem;font-weight:600;display:flex}label.check{color:var(--text);background:var(--surface);border:1px solid var(--border);cursor:pointer;border-radius:999px;flex-direction:row;align-items:center;gap:.6rem;min-height:2.9rem;padding:0 1rem;font-size:.95rem;font-weight:500;display:inline-flex}label.check:has(input:checked){border-color:var(--accent);background:var(--accent-soft)}input,select,textarea{font:inherit;color:var(--text);background:var(--surface);border:1px solid var(--border);border-radius:12px;min-height:2.9rem;padding:.6rem .9rem;font-size:.975rem}input:hover,select:hover,textarea:hover{border-color:var(--border-strong)}input:focus-visible,select:focus-visible,textarea:focus-visible{border-color:var(--accent);box-shadow:0 0 0 4px var(--accent-ring);outline:none}select{appearance:none;cursor:pointer;background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 24 24' fill='none' stroke='%236b6f78' stroke-width='2' stroke-linecap='round'%3E%3Cpath d='M6 9l6 6 6-6'/%3E%3C/svg%3E");background-position:right .8rem center;background-repeat:no-repeat;background-size:1rem;padding-right:2.4rem}input[type=checkbox]{width:1.2rem;height:1.2rem;min-height:0;accent-color:var(--accent);padding:0}input[type=search]{background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 24 24' fill='none' stroke='%236b6f78' stroke-width='2' stroke-linecap='round'%3E%3Ccircle cx='11' cy='11' r='7'/%3E%3Cpath d='M20 20l-3.5-3.5'/%3E%3C/svg%3E");background-position:.85rem;background-repeat:no-repeat;background-size:1.05rem;min-width:18rem;padding-left:2.5rem}.filter-count{margin:0 0 .7rem auto;font-size:.9rem}.empty{text-align:center;padding:2rem}.see-also-grid{grid-template-columns:repeat(auto-fit,minmax(min(100%,22rem),1fr));gap:1rem;margin-top:2.5rem;display:grid}.see-also-grid .see-also{margin-top:0}.see-also{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius);color:var(--text);box-shadow:var(--shadow-sm);justify-content:space-between;align-items:center;gap:1rem;margin-top:2.5rem;padding:1.4rem 1.6rem;text-decoration:none;display:flex}.see-also:hover{color:var(--text);border-color:var(--border-strong);box-shadow:var(--shadow);text-decoration:none}.see-also>span:first-child{gap:.15rem;display:grid}.see-also .arrow{color:var(--accent);font-size:1.4rem}.table-wrap{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius-lg);box-shadow:var(--shadow);overflow-x:auto}.sticky-head{top:var(--header-h,0px);z-index:10;visibility:hidden;background:var(--surface-2);border:1px solid var(--border);box-shadow:var(--shadow-sm);border-top:0;position:sticky;overflow:hidden}.sticky-head.is-stuck{visibility:visible}.sticky-head .drug-table{table-layout:fixed}.drug-table{border-collapse:separate;border-spacing:0;width:100%;font-size:.925rem;line-height:1.45}.drug-table>thead th{text-align:left;text-transform:uppercase;letter-spacing:.07em;color:var(--muted);border-bottom:1px solid var(--border);white-space:nowrap;background:var(--surface-2);padding:.95rem .9rem;font-size:.72rem;font-weight:650}.drug-table>thead th:first-child{padding-left:1.4rem}.drug-table>tbody>tr>th,.drug-table>tbody>tr>td{text-align:left;vertical-align:top;border-bottom:1px solid var(--border);padding:.35rem .3rem;font-weight:400}.drug-table>tbody>tr>th{padding-left:.8rem}.drug-table>tbody>tr:last-child>*{border-bottom:0}.drug-table>tbody>tr:hover>*{background:var(--surface-2)}.cell-button{text-align:left;width:100%;min-height:100%;font:inherit;color:inherit;cursor:pointer;background:0 0;border:1px solid #0000;border-radius:12px;padding:.7rem .6rem;display:block}.cell-button:hover{background:var(--surface);border-color:var(--border);box-shadow:var(--shadow-sm)}.cell{flex-direction:column;align-items:flex-start;gap:.35rem;display:flex}.drug-name{letter-spacing:-.01em;font-size:1.05rem;font-weight:700}.main{font-weight:600}.plain{color:var(--text)}.sub{color:var(--muted);font-size:.84rem}.checked{color:var(--muted);margin-top:.15rem;font-size:.75rem}.clamp-1,.clamp-2,.clamp-3{-webkit-box-orient:vertical;display:-webkit-box;overflow:hidden}.clamp-1{-webkit-line-clamp:1;line-clamp:1}.clamp-2{-webkit-line-clamp:2;line-clamp:2}.clamp-3{-webkit-line-clamp:3;line-clamp:3}.drug-table>tbody>tr>th{width:12%;min-width:10rem}.drug-table>tbody>tr>td{min-width:9.5rem}.stage-meter{grid-template-columns:repeat(4,1.6rem);gap:3px;display:inline-grid}.stage-meter i{background:var(--surface-3);border:1px solid var(--border);border-radius:3px;height:6px}.stage-meter i.is-full{background:var(--accent);border-color:var(--accent)}.stage-meter i.is-half{background:linear-gradient(90deg, var(--accent) 50%, var(--surface-3) 50%);border-color:var(--accent)}.stage-approved i.is-full{background:var(--text-2);border-color:var(--text-2)}.badge-info{background:var(--accent-soft);color:var(--accent)}.note-info{background:var(--accent-soft);color:var(--accent-ink)}.badge-lg{font-family:var(--font-sans);vertical-align:middle;letter-spacing:0;padding:.3rem .8rem;font-size:.95rem}.bottom-line{border-left:3px solid var(--text);background:var(--surface-2);border-radius:0 12px 12px 0;margin:0 0 1.1rem;padding:.9rem 1.1rem}.bottom-line p{color:var(--text);margin:0;font-weight:500}.bottom-line .eyebrow{margin-bottom:.25rem}.bottom-line-lg{background:var(--surface);border:1px solid var(--border);border-left:4px solid var(--text);max-width:46rem;margin:1.25rem 0}.bottom-line-lg p:not(.eyebrow){font-size:1.15rem;line-height:1.5}.effect-box{border:1px solid var(--border);border-radius:12px;margin:1rem 0;padding:.9rem 1.1rem}.effect-box p{margin:0}.effect-headline{color:var(--text);font-weight:650}.effect-absolute{color:var(--text-2);margin-top:.2rem!important}.study-list{gap:.6rem;margin:.75rem 0 1rem;padding:0;list-style:none;display:grid}.study{border:1px solid var(--border);background:var(--surface);border-radius:12px;grid-template-columns:2rem 1fr;gap:.75rem;padding:.85rem 1rem;display:grid}.study p{margin:0}.study-mark{background:var(--neutral-bg);width:2rem;height:2rem;color:var(--neutral);border-radius:50%;place-items:center;font-weight:700;display:grid}.study-good .study-mark{background:var(--good-bg);color:var(--good)}.study-caution .study-mark{background:var(--caution-bg);color:var(--caution)}.study-bad .study-mark{background:var(--bad-bg);color:var(--bad)}.study-title{color:var(--text);flex-wrap:wrap;align-items:center;gap:.4rem .6rem;display:flex}.study-meta{color:var(--muted);font-size:.82rem;margin-top:.15rem!important}.study-summary{color:var(--text-2);font-size:.925rem;margin-top:.35rem!important}.reg-chips{flex-wrap:wrap;gap:.25rem;display:flex}.reg-chip{border:1px solid var(--border);background:var(--surface);color:var(--text-2);white-space:nowrap;border-radius:6px;align-items:center;gap:.2rem;padding:.1rem .45rem;font-size:.74rem;font-weight:600;display:inline-flex}.reg-partial{border-style:dashed}.reg-waiting{color:var(--muted)}.reg-no{background:var(--bad-bg);color:var(--bad);border-color:#0000}.reg-more{color:var(--muted)}.flag{color:var(--caution);align-items:center;gap:.3rem;font-size:.74rem;font-weight:650;display:inline-flex}.flag:before{content:"!";background:var(--caution-bg);border-radius:50%;place-items:center;width:1rem;height:1rem;font-size:.7rem;display:grid}.reg-list{gap:.5rem;margin:.5rem 0 1rem;padding:0;list-style:none;display:grid}.reg-list li{border:1px solid var(--border);border-radius:10px;grid-template-columns:minmax(8rem,1fr) 2fr;gap:.15rem 1rem;padding:.7rem .9rem;font-size:.925rem;display:grid}.reg-list li.reg-no .reg-decision{color:var(--bad);font-weight:600}.reg-note{color:var(--muted);grid-column:2;font-size:.85rem}.panel-wide{max-width:60rem}.badge,.tag{white-space:nowrap;border-radius:999px;align-items:center;padding:.15rem .55rem;font-size:.75rem;font-weight:600;line-height:1.5;display:inline-flex}.badge-good{background:var(--good-bg);color:var(--good)}.badge-caution{background:var(--caution-bg);color:var(--caution)}.badge-bad{background:var(--bad-bg);color:var(--bad)}.badge-neutral{background:var(--neutral-bg);color:var(--neutral)}.tag{background:var(--surface-3);color:var(--text-2);border:1px solid var(--border)}.tag-company{background:var(--accent-soft);color:var(--accent);border-color:#0000}.tags{flex-wrap:wrap;gap:.3rem;display:flex}.status-dot{color:var(--muted);align-items:center;gap:.45rem;font-size:.875rem;font-weight:600;display:inline-flex}.status-dot:before{content:"";background:var(--border-strong);border-radius:50%;width:.55rem;height:.55rem}.status-dot.is-on{color:var(--good)}.status-dot.is-on:before{background:var(--good);box-shadow:0 0 0 3px var(--good-bg)}.status-dot.is-alt{color:var(--accent);font-size:.8rem}.status-dot.is-alt:before{background:var(--accent)}.note{border-radius:12px;padding:.85rem 1rem;font-size:.95rem}.note-good{background:var(--good-bg);color:var(--good)}.note-caution{background:var(--caution-bg);color:var(--caution)}.note-bad{background:var(--bad-bg);color:var(--bad)}.note-neutral{background:var(--neutral-bg);color:var(--neutral)}.signal{white-space:nowrap;align-items:center;gap:.5rem;font-weight:650;display:inline-flex}.signal-bars{align-items:flex-end;gap:2px;height:.95rem;display:inline-flex}.signal-bars i{background:var(--border-strong);border-radius:2px;width:4px}.signal-bars i:first-child{height:30%}.signal-bars i:nth-child(2){height:55%}.signal-bars i:nth-child(3){height:78%}.signal-bars i:nth-child(4){height:100%}.signal-active{color:var(--good)}.signal-steady{color:var(--accent)}.signal-quiet{color:var(--caution)}.signal-silent{color:var(--bad)}.signal-active .signal-bars i,.signal-steady .signal-bars i:nth-child(-n+3),.signal-quiet .signal-bars i:nth-child(-n+2),.signal-silent .signal-bars i:first-child{background:currentColor}.breakdown{border-collapse:collapse;width:100%;margin:1.1rem 0;font-size:.92rem}.breakdown th,.breakdown td{text-align:left;border-bottom:1px solid var(--border);vertical-align:top;padding:.65rem .5rem}.breakdown th{font-weight:600}.breakdown thead th{text-transform:uppercase;letter-spacing:.06em;color:var(--muted);font-size:.75rem}.breakdown tfoot th,.breakdown tfoot td{border-bottom:0}.breakdown .pts{text-align:right;white-space:nowrap;font-variant-numeric:tabular-nums}.milestones{gap:.5rem;margin:0;padding:0;list-style:none;display:grid}.milestones li{background:var(--surface-2);border:1px solid var(--border);border-radius:10px;padding:.6rem .8rem;font-size:.925rem}.verdict{margin-right:.35rem;font-size:.8rem;font-weight:650;display:inline-block}.verdict-on-time .verdict{color:var(--good)}.verdict-late .verdict{color:var(--caution)}.verdict-overdue .verdict,.verdict-abandoned .verdict{color:var(--bad)}.verdict-upcoming .verdict{color:var(--muted)}.popup{border:1px solid var(--border);border-radius:var(--radius-lg);background:var(--surface);width:min(42rem,100vw - 1.5rem);max-height:min(48rem,100vh - 3rem);color:var(--text);box-shadow:var(--shadow-lg);padding:0;font-size:1rem;line-height:1.6}.popup[open]{flex-direction:column;display:flex}.popup::backdrop{-webkit-backdrop-filter:blur(3px);background:#11121573}@media (prefers-reduced-motion:no-preference){.popup[open]{animation:.22s cubic-bezier(.2,.9,.3,1.1) pop-in}.popup[open]::backdrop{animation:.2s fade-in}}@keyframes pop-in{0%{opacity:0;transform:translateY(12px)scale(.98)}}@keyframes fade-in{0%{opacity:0}}.popup-head{justify-content:space-between;align-items:flex-start;gap:1rem;padding:1.5rem 1.75rem .75rem;display:flex}.popup-head h2{margin:.3rem 0 0;font-size:1.6rem;line-height:1.2}.popup-close{border:1px solid var(--border);background:var(--surface);width:2.75rem;height:2.75rem;color:var(--text);cursor:pointer;border-radius:50%;flex:none;place-items:center;display:grid}.popup-close:hover{background:var(--surface-3)}.popup-body{color:var(--text-2);padding:.25rem 1.75rem 1.25rem;overflow-y:auto}.popup-body p{margin:0 0 .9rem}.popup-body h3{color:var(--text);margin:1.4rem 0 .6rem}.popup-cta{margin-top:1.25rem!important}.meta-line{color:var(--muted);font-size:.875rem;display:block}.trial-list{gap:.6rem;margin:0;padding:0;list-style:none;display:grid}.trial-list li{border:1px solid var(--border);border-radius:10px;padding:.7rem .9rem}.popup-foot{border-top:1px solid var(--border);background:var(--surface-2);border-radius:0 0 var(--radius-lg) var(--radius-lg);justify-content:space-between;align-items:center;gap:1rem;padding:.75rem 1.75rem;display:flex}.sources{border-top:1px solid var(--border);margin-top:1.5rem;padding-top:1.1rem;font-size:.9rem}.sources h3{text-transform:uppercase;letter-spacing:.08em;color:var(--muted);margin:0 0 .6rem;font-size:.72rem;font-weight:650}.sources ol{gap:.55rem;margin:0;padding-left:1.4rem;display:grid}.sources li::marker{color:var(--muted);font-variant-numeric:tabular-nums}.sources li a{font-weight:500}.sources li .muted{font-size:.8rem;display:block}.breadcrumb{margin:1.75rem 0 0;font-size:.95rem}.breadcrumb a{color:var(--muted);text-decoration:none}.breadcrumb a:hover{color:var(--text)}.drug-header{padding-bottom:1rem}.drug-header h1{margin:.6rem 0 .4rem}.status{text-transform:uppercase;letter-spacing:.07em;border-radius:999px;margin:1rem 0 0;padding:.3rem .75rem;font-size:.75rem;font-weight:650;display:inline-block}.status-in-development{background:var(--accent-soft);color:var(--accent)}.status-approved{background:var(--neutral-bg);color:var(--text)}.status-discontinued{background:var(--neutral-bg);color:var(--neutral)}.fact-grid{grid-template-columns:repeat(auto-fill,minmax(min(100%,21rem),1fr));align-items:start;gap:.9rem;display:grid}.fact{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius);box-shadow:var(--shadow-sm)}.fact:hover{border-color:var(--border-strong)}.fact[open]{box-shadow:var(--shadow)}.fact summary{cursor:pointer;border-radius:var(--radius);flex-direction:column;gap:.25rem;padding:1.15rem 1.3rem;list-style:none;display:flex}.fact summary::-webkit-details-marker{display:none}.fact-title{text-transform:uppercase;letter-spacing:.08em;color:var(--muted);font-size:.72rem;font-weight:650}.fact-value{font-size:1.1rem;font-weight:650;line-height:1.35}.fact .aka{color:var(--muted);font-size:.875rem}.fact-more{color:var(--accent);margin-top:.5rem;font-size:.85rem;font-weight:600}.fact-more:after{content:" ↓"}.fact[open] .fact-more:after{content:" ↑"}.fact-body{border-top:1px solid var(--border);color:var(--text-2);padding:1rem 1.3rem 1.2rem;font-size:.975rem}.fact-body p:first-child{margin-top:0}.panel{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius-lg);box-shadow:var(--shadow-sm);max-width:52rem;margin-top:2.5rem;padding:.5rem 1.75rem 1.25rem}.panel h2{align-items:center;gap:.75rem;display:flex}.timeline-year h3{font-family:var(--font-display);margin:2rem 0 1rem;font-size:1.4rem;font-weight:500}.timeline{border-left:2px solid var(--border);max-width:54rem;margin:0 0 0 .4rem;padding:0;list-style:none}.event{grid-template-columns:7.5rem 1fr;gap:1.25rem;padding:0 0 1.75rem 1.5rem;display:grid;position:relative}.event:before{content:"";background:var(--bg);border:2px solid var(--border-strong);border-radius:50%;width:12px;height:12px;position:absolute;top:.4rem;left:-7px}.event-company:before{background:var(--accent);border-color:var(--accent);box-shadow:0 0 0 4px var(--accent-soft)}.event time{color:var(--muted);font-variant-numeric:tabular-nums;padding-top:.15rem;font-size:.875rem}.event h4{margin:.4rem 0 .25rem;font-size:1.05rem;line-height:1.35}.event h4 a{color:var(--text);text-decoration:none}.event h4 a:hover{color:var(--accent);text-decoration:underline}.event p{color:var(--text-2);margin:0}.event-meta{flex-wrap:wrap;align-items:center;gap:.4rem;font-size:.8rem;display:flex}.prose{max-width:44rem;padding-top:clamp(1.5rem,4vw,3rem)}.prose h2{margin-top:2.2em}.prose p,.prose li,.prose dd{color:var(--text-2)}.prose dt{margin-top:1.1rem;font-weight:650}.prose dd{margin:.2rem 0 0}.glossary dt{border-top:1px solid var(--border);padding-top:1.1rem;scroll-margin-top:5.5rem;font-size:1.05rem}.glossary dt:target{color:var(--accent)}.evidence-list{gap:.7rem;padding:0;list-style:none;display:grid}.changelog-entry{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius);margin-top:1.25rem;padding:.25rem 1.5rem .75rem}.changelog-entry h2{margin-top:1rem;font-size:1.25rem}.intro-turn{font-family:var(--font-display);color:var(--text);margin-top:1.75rem;font-size:1.3rem;font-style:italic}.pull-quote{border-left:3px solid var(--accent);margin:2rem 0;padding:.25rem 0 .25rem 1.4rem}.pull-quote p{font-family:var(--font-display);letter-spacing:-.01em;color:var(--text);margin:0;font-size:clamp(1.35rem,2.4vw,1.65rem);font-weight:480;line-height:1.35}.question-list,.not-list{grid-template-columns:repeat(2,minmax(0,1fr));gap:.75rem;margin:1.25rem 0 1.5rem;padding:0;list-style:none;display:grid}.prose .question-list li{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius);color:var(--text);padding:.9rem 1.1rem;font-weight:520;line-height:1.45}.prose .not-list li{background:var(--surface-2);border:1px solid var(--border);border-radius:var(--radius);padding:1.1rem 1.2rem;font-size:.97rem}.not-list strong{color:var(--text);font-family:var(--font-display);margin-bottom:.3rem;font-size:1.12rem;font-weight:560;line-height:1.3;display:block}.author{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius-lg);box-shadow:var(--shadow);margin-top:1.25rem;padding:1.6rem 1.75rem 1.5rem}.author-head{border-bottom:1px solid var(--border);align-items:center;gap:1.25rem;margin-bottom:1.1rem;padding-bottom:1.25rem;display:flex}.author-photo{object-fit:cover;object-position:50% 40%;width:7.5rem;height:7.5rem;box-shadow:0 0 0 4px var(--surface), 0 0 0 5px var(--border-strong);border-radius:50%;flex:none}.prose .author-name{font-family:var(--font-display);letter-spacing:-.015em;color:var(--text);margin:0;font-size:1.6rem;font-weight:560;line-height:1.15}.prose .author-role{color:var(--muted);margin:.3rem 0 .55rem;font-size:.97rem;line-height:1.45}.author-link{font-size:.95rem;font-weight:600}.author-copy p:last-child{margin-bottom:0}.closing{border-top:1px solid var(--border-strong);margin-top:3rem;padding-top:1.75rem}.prose .closing p{font-family:var(--font-display);letter-spacing:-.015em;color:var(--text);margin:0;font-size:clamp(1.4rem,2.6vw,1.8rem);font-weight:500;line-height:1.3}.closing-sign{color:var(--muted);align-items:center;gap:.75rem;margin-top:1.1rem;font-size:.95rem;display:flex}.closing-sign img{object-fit:cover;object-position:50% 40%;border-radius:50%;width:2.5rem;height:2.5rem}@media (width<=560px){.question-list,.not-list{grid-template-columns:1fr}.author{padding:1.2rem}.author-head{gap:1rem}.author-photo{width:5.5rem;height:5.5rem}.prose .author-name{font-size:1.35rem}}.contact-form{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius-lg);max-width:36rem;box-shadow:var(--shadow-sm);gap:1.1rem;padding:1.5rem;display:grid}.contact-form label{gap:.35rem;font-size:.925rem;font-weight:600;display:grid}.contact-form .button{justify-self:start}.subscribe-form{gap:1.1rem;display:grid}.subscribe-form label{gap:.35rem;font-size:.925rem;font-weight:600;display:grid}.subscribe-form input,.subscribe-form select{width:100%}.subscribe-stacked{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius-lg);max-width:36rem;box-shadow:var(--shadow-sm);margin-top:1.5rem;padding:1.5rem}.subscribe-stacked .button{justify-self:start}.subscribe-inline{grid-template-columns:repeat(3,minmax(0,1fr)) auto;align-items:end;gap:.75rem}.subscribe-inline .button{min-height:2.9rem}.subscribe-fine{grid-column:1/-1;margin:0;font-size:.85rem}.subscribe-box{background:var(--accent-soft);border:1px solid color-mix(in srgb, var(--accent) 18%, transparent);border-radius:var(--radius-lg);margin:2rem 0;padding:1.5rem}.subscribe-box h2{margin:0 0 .3rem}.subscribe-box>p,.subscribe-box>div>p{margin:0 0 1rem}.subscribe-band{grid-template-columns:minmax(0,1fr) minmax(0,2fr);align-items:center;gap:1rem 2.5rem;margin-top:2.5rem;padding:1.75rem 2rem;display:grid}.subscribe-band>div>p{margin:0}@media (width<=1080px){.subscribe-band{grid-template-columns:1fr}}@media (width<=720px){.subscribe-inline{grid-template-columns:1fr}.subscribe-inline .button{justify-self:start}.subscribe-band{padding:1.25rem}}.contact-context{border-radius:var(--radius);background:var(--accent-soft);color:var(--accent-ink);margin:0;padding:.8rem 1rem;font-size:.925rem}.contact-context a{margin-top:.3rem;font-size:.875rem;display:block}.contact-context strong{text-transform:uppercase;letter-spacing:.07em;font-size:.75rem;display:block}@media (width<=1080px){.hero{grid-template-columns:1fr;align-items:start}.stats{grid-template-columns:repeat(4,1fr)}}@media (width<=960px){.sticky-head{display:none}.table-wrap{box-shadow:none;background:0 0;border:0;overflow:visible}.drug-table,.drug-table>tbody,.drug-table>tbody>tr,.drug-table>tbody>tr>th,.drug-table>tbody>tr>td{width:100%;display:block}.drug-table>thead{clip:rect(0 0 0 0);width:1px;height:1px;position:absolute;overflow:hidden}.drug-table>tbody>tr{background:var(--surface);border:1px solid var(--border);border-radius:var(--radius-lg);box-shadow:var(--shadow-sm);grid-template-columns:1fr 1fr;margin-bottom:1rem;padding:.5rem;display:grid}.drug-table>tbody>tr:hover>*{background:0 0}.drug-table>tbody>tr[hidden]{display:none}.drug-table>tbody>tr>th{border-bottom:1px solid var(--border);grid-column:1/-1;min-width:0;margin-bottom:.25rem;padding:0}.drug-table>tbody>tr>td{border-bottom:0;min-width:0;padding:0}.drug-table>tbody>tr>td:before{content:attr(data-label);text-transform:uppercase;letter-spacing:.07em;color:var(--muted);padding:.6rem .6rem 0;font-size:.68rem;font-weight:650;display:block}.drug-table>tbody>tr>td .cell-button{padding-top:.25rem}.drug-table>tbody>tr>th .drug-name{font-family:var(--font-display);font-size:1.45rem;font-weight:560}.clamp-3{-webkit-line-clamp:4;line-clamp:4}.filters label:first-child{flex:100%}input[type=search]{width:100%;min-width:0}.filter-count{width:100%;margin:0}.stats{grid-template-columns:repeat(2,1fr)}.event{grid-template-columns:1fr;gap:.1rem}.site-header nav{scrollbar-width:none;order:3;width:100%;margin:0 -.25rem;overflow-x:auto}.site-header nav::-webkit-scrollbar{display:none}.site-header nav ul{flex-wrap:nowrap}.site-header nav a{white-space:nowrap}}@media (width<=560px){body{font-size:1rem}.drug-table>tbody>tr>td[data-label="How it works"]{grid-column:1/-1}.drug-table,.site-header nav a{font-size:.9rem}.popup-head,.popup-body,.popup-foot{padding-left:1.2rem;padding-right:1.2rem}.see-also{padding:1.1rem 1.2rem}}@media (prefers-reduced-motion:no-preference){.cell-button,.site-header nav a,.button,.see-also,label.check{transition:background-color .15s,border-color .15s,box-shadow .15s,color .15s}}
